I. Introduction:

I.a Basic of Mass Spectrometry

I.b Major Applications of Mass Spectrometry

I.c Vacuum Science and Technology

II. Ionization:

II.a Electron Ionization

II.b Chemical Ionization

II.c Photoionization

II.d Matrix-assisted Laser Desorption/Ionization

II.e Electrospray Ionization

II.f Other Ionization methods: FAB, Field Ionization, SIMS etc.

II.g Major challenges for Future Development

III. Mass Analysis:

III.a Quadrupole

III.b Ion Trap

III.c Time-of-flight

III.d Magnetic Sector

III.e FTICR

III.f Major Challenges for Future Development

IV. Detection:

IV.a Charge Collector

IV.b Charge Amplifier Detector

IV.c Scientillator Detector

IV.d Other Detectors and Major Barriers to Overome.

V. Tandem Mass Spectrometry

V.a Basic of MS/MS

V.b Collision induced Dissociation

V.c Ion-Molecule Interaction

VI. Chromatography/Mass Spectrometer Coupling

VI.a GC/MS

VI.b LC/MS

VI.c CE/MS

VII Biomolecule Analysis

VII.a Oligonucleotide, Protein, Polysaccharide Analysis

VII.b DNA Analysis and Sequencing

VII.c Proteomic & Metabolomic Applications

VII.d Disease Diagnosis

VIII Other Applications

VIII.a Trace Element Analysis

VIII.b Organic Polymer Analysis

VIII.c Environmental Application

VIII.d Material Analysis

IX Future Challenges:

I X.a Ionization Mechanism

IX.b Mass to Charge Ratio Extension

IX.c Quantitative Measurements

IX.d Dynamic Range Extension

IX.e Cost Reduction

IX.f Size Reduction

X. Conclusion